The OD's Guide to the Diagnosis and Management of Cranial Nerve IV Palsy

Fourth cranial nerve palsies (FCNP) have many implications on vision and development, and an ODs' understanding of this common cause of vertical strabismus can have major impacts on patients' lives.

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Updated Sep 16, 2020
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👨‍🎓 What You'll Learn
  • Recognize the unique features of FCNP
  • Know the common tests for FCNP and their diagnostic reliability
  • Understand when neuroimaging is indicated for FCNP

Introduction and Quiz

It is well recognized that a fourth cranial nerve palsy is a common cause of vertical strabismus in children and adults. However, just the idea of vertical strabismus or diplopia can elicit a visceral reaction from eye care providers. The objectives for this course are to specifically recognize the causes, clinical presentation, and management of fourth cranial nerve palsies (FCNP). Because of the implications of FCNP on vision development, social concerns, and possible adverse health outcomes, increasing our understanding in this topic can have a far-reaching impact in our patients’ lives.

Quiz: Cranial Nerve IV Palsy

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Background and Etiology

Background

To understand FCNP, we must first review the normal physiology of the fourth cranial nerve and the superior oblique muscle (SOM). The fourth cranial nerve, the trochlear nerve, is one of the three cranial nerves that innervate the six extraocular muscles of the eye. This nerve takes a long trip from the brainstem to its final destination of the superior oblique muscle. Starting from the midbrain, the nerve exits dorsally, runs in the subarachnoid space, and enters the cavernous sinus. It then travels through the superior orbital fissure to innervate the SOM.

Unique features of CN IV:

  • Has the longest intracranial course (susceptible to damage by trauma)
  • Exits from the rear of the brainstem (the only cranial nerve that does!)
  • Innervates a single muscle contralateral to its nucleus (all other cranial nuclei affect the ipsilateral side)

The SOM intorts, depresses, and abducts the eye. These actions arise from the relationship between the trochlea on the frontal bone and the angled insertion of the muscle on the posterior half of the eye.

Unique features of SOM

  • Utilizes a pulley system with the trochlea
  • Highlights different actions in different positions of horizontal gaze (better depression in adduction, better intorsion in abduction)

superior oblique muscles

Source: UT Health Department of Neurobiology and Anatomy, color added for emphasis

Etiology

The majority of FCNP are congenital,1,2 but that is not synonymous with presentation in childhood exclusively. FCNP can have a delayed presentation into adulthood due to decompensation of the deviation.1 Recent research using MRI has differentiated congenital FCNP into two sub-types. Nearly three-fourths of patients with congenital FCNP actually lack a fourth cranial nerve and have a subsequent hypoplastic SOM, while the other fourth of patients have normal nerves and muscles.3

Trauma and microvascular disease are considered the most common causes of acquired FCNP. Even a mild blow to the head can cause a traumatic FCNP,4 and tends to be bilateral due to the anatomical course of the nerve. Microvascular disease such as hypertension and diabetes affects more commonly cranial nerves three and six,5 but has been shown to be involved in FCNP in approximately one-fifth to one-fourth of cases.1,2 Intracranial neoplasms are considered a rare cause1 and would often present with other neurological deficits, depending on the location of the lesion.


Diagnosis and Treatment

Clinical Characteristics

The classic picture of FCNP is a hypertropia that is worse on ipsilateral head tilt and ipsilateral face turn. As a result, patients with FCNP usually adopt a head tilt away and chin tuck from the affected eye to decrease the vertical misalignment6. However, there are many variations from this presentation. Within the sub-types of congenital FCNP, head tilt may appear earlier in patients with an absent nerve versus a functioning nerve.3 Patients with congenital FCNP who have a normal nerve may show a nasal upshoot or dissociated vertical deviation.3 A larger hypertropia in up gaze than down gaze can distinguish a congenital FCNP from an acquired FCNP.7 The horizontal deviation can also suggest the type of FCNP, with an exodeviation associated with microvascular acquired FCNP and an esodeviation with congenital FCNP.8 These paradoxical compensations may be due to a combination of underaction and overaction of other muscles.

Tests traditionally utilized to understand the type of FCNP have not been validated for diagnostic purposes. Most widely used is the Parks-Bielschowsky three-step test, which, when evaluated, has only a 50% to 70% sensitivity.9,10 Looking only at hypertropia in primary gaze and in head tilt increases sensitivity to 84%.9 Larger vertical fusional amplitudes were previously thought to be paradigmatic for congenital FCNP, but are not consistently so.7 Torsional misalignment is another factor with mixed diagnostic reliability.7,11

BMJ image of incomitance in right fourth nerve palsy

Source: The BMJ

Work-up and Treatment

Gathering pertinent information from your clinical exam is foremost, with special emphasis on patient history and binocularity testing. It is important to check for comitancy with cover testing in multiple positions of gaze. The phone app called 9 Gaze is a great supplementary tool for documenting extraocular motility testing. The three-step test, vertical fusional amplitudes, and torsional misalignment can add pieces of the puzzle, but should not be used to hang our hats on.

Management options focus on restoring binocular function and diplopia. For children with a congenital FCNP, early intervention is warranted for binocular vision development and ergonomic posture. Strabismus surgery has the potential for large changes in the amount of vertical deviation and head tilt.12 Watchful waiting for isolated FCNP can be appropriate, as clinical courses can normalize with time. The majority of FCNP due to microvascular disease can resolve spontaneously within 10 months without any intervention.14 Similarly, prognosis is favorable for recovery from traumatic FCNP within 6 months.15 While waiting for resolution, prisms up to 15 prism diopters can provide relief for patients with symptomatic diplopia.13 Occlusion can also be considered as an option to eliminate diplopia and improve torticollis.


Conclusion and References

The role of neuroimaging is evolving with emerging evidence and the variability of presentation of FCNP. Imaging is undeniably indicated for non-isolated (i.e., without other neurological deficits) FCNP and MRI would be the preferred evaluation method over CT. The yield for imaging on isolated FCNP is generally low,16 although there are studies and case reports supporting the use of neuroimaging to detect other potential comorbid causes.5,17,18 In conclusion, the level of concern should be driven by the total clinical picture, and neuroimaging can be used to corroborate clinical findings.

You're done with the course—head back to the quiz to find out what you've learned!

References

  1. Dosunmu E et al. Incidence and Etiology of Presumed Fourth Cranial Nerve Palsy: A Population-based Study. Am J Ophthalmol 2018.
  2. Mollan SP et al. Aetiology and outcomes of adult superior oblique palsies: a modern series. Eye (Lond) 2009.
  3. Yang HK et al. Congenital superior oblique palsy and trochlear nerve absence. A clinical and radiological study. Ophthalmology 2012.
  4. Dhaliwal A et al. Third, fourth, and sixth cranial nerve palsies following closed head injury. J Neuroophthalmol 2006.
  5. Tamhankar MA et al. Isolated third, fourth, and sixth cranial nerve palsies from presumed microvascular versus other causes: a prospective study. Ophthalmology 2013.
  6. Kushner BJ. The influence of head tilt on ocular torsion in patients with superior oblique muscle palsy. J AAPOS 2009.
  7. Ivanir Y, Trobe JD. Comparing Hypertropia in Upgaze and Downgaze Distinguishes Congenital From Acquired Fourth Nerve Palsies. J Neuroophthalmol 2017.
  8. Hata M et al. Horizontal deviation as diagnostic and prognostic values in isolated fourth nerve palsy. Br J Ophthalmol 2013.
  9. Manchandia AM, Demer JL. Sensitivity of the three-step test in diagnosis of superior oblique palsy. J AAPOS 2014.
  10. Kono R et al. Absence of relationship between oblique muscle size and bielschowsky head tilt phenomenon in clinically diagnosed superior oblique palsy. Invest Ophthalmol Vis Sci 2009.
  11. Kim DH, Lim HT. Comparison of ocular torsion between congenital and acquired unilateral superior oblique palsy. Eye (Lond) 2019.
  12. Kekunnaya R, Isenberg S J. Effect of strabismus surgery on torticollis caused by congenital superior oblique palsy in young children. Indian J Ophthalmol 2014.
  13. Tamhankar MA et al. Success of prisms in the management of diplopia due to fourth nerve palsy. J Neuroophthalmol 2011.
  14. Khaier A et al. Clinical Course and characteristics of acute presentation of fourth nerve paresis. J Pediatr Ophthalmol Strabismus 2012.
  15. Park UC et al. Clinical features and natural history of acquired third, fourth, and sixth cranial nerve palsy. Eye (Lond) 2008.
  16. Murchison AP et al. Neuroimaging and acute ocular motor mononeuropathies: a prospective study. Arch Ophthalmol 2011.
  17. Tamhankar MA, Volpe NJ. Management of acute cranial 3, 4, and 6 palsies: role of neuroimaging. Curr Opinion Ophthalmol 2015.
  18. Sudhakar P et al. CT demonstration of dorsal midbrain hemorrhage in traumatic fourth cranial nerve palsy. J Neuroophthalmol 2010.
About Tiffany Yanase Park, OD

Dr. Tiffany Yanase Park graduated magna cum laude from Southern California College of Optometry and completed a pediatric optometry residency at Children’s Hospital Colorado. Her training focused on pediatric primary care, ocular disease, low vision, and specialty contact lenses. Dr. Yanase Park now works as part of a university-based pediatric ophthalmology department in Southern California.